How we achieve our goal
The proposed work is organised into four research work packages (WPs), one dissemination and exploitation WP and the project management WP. The research work is organised around methodological approaches, including epidemiological and physiological studies, in vivo and in vitro experiments as well as molecular-genetic analysis:
- Work package 1 provides quantification of the transmission of MRSA ST398 between animals and humans and the risk for health care settings. The data collected in this WP are used in WP4.
- Work package 2 provides in vivo and in vitro models to study factors relevant for the colonisation, host range and virulence of MRSA. WP2 interlinks with WP3 and provides the animal models used in WP4.
- Work package 3, in close interaction with WP2, identifies key genetic components of the specific interaction between S. aureus ST398 and its hosts. Findings will feed back to WP2 to test identified factors using knock-out technology. Additionally, WP3 identifies specific genes for the development of new rapid tests to identify specific MRSA strains and potentially for bed-side testing.
- Work package 4 develops novel intervention technology based on decolonisation and environmental sanitation using photocatalysis and electrochemically generated charged metal ion solutions as well as antagonism. It is linked with WP5 to provide the technical components of the Technology Testing Platform (TTP).
- Work package 5 integrates findings to provide and communicate a range of recommendations and guidelines for risk management, including the proposition of novel control strategies. The TTP from WP4 will be made available to companies for validation of existing and new solutions targeted at nosocomial infections under standardised and realistic conditions.
- Work package 6 assures efficient scientific and administrational management and effective internal and external cooperation.